Doctor of Medicine, Chief Physician, Professor, Doctoral Supervisor. Recipient of National Talent Program, Expert with Special Government Allowance. **Expertise:** Long-term dedication to the surgical treatment, perioperative comprehensive therapy, and translational medicine research of lung cancer and esophageal cancer. Main research areas: Surgical treatment and enhanced recovery after surgery (ERAS) for complex and difficult lung and esophageal cancers; clinical research on novel drugs for complex and difficult thoracic tumors; development and application of biomarkers for early diagnosis and differential diagnosis of thoracic tumors; integration of novel digital technologies with the full-process management of lung cancer diagnosis and treatment. **Concurrent Positions:** Member of the Staging and Prognostic Factors Committee of the International Association for the Study of Lung Cancer (IASLC). Member of the Oncology Branch of the Chinese Medical Association. Standing Committee Member of the Thoracic Surgery Branch and the Multidisciplinary Diagnosis and Treatment Committee of the Chinese Medical Doctor Association. Standing Committee Member of the Thoracic Surgery Branch of the China International Exchange and Promotive Association for Medical and Health Care. Vice Chairman of the Smart Medical Expert Committee and Member of the Non-Small Cell Lung Cancer Expert Committee of the Chinese Society of Clinical Oncology (CSCO). Vice Chairman of the Oncology Branch and Standing Committee Member of the Thoracic Surgery Branch of the Beijing Medical Association. Has led multiple national, provincial, and ministerial-level scientific research projects. Currently has published over 90 papers in international peer-reviewed journals, with representative publications in major international journals such as *Cell Discovery*, *Molecular Cancer*, *STTT*, *Cell Stem Cell*, *PNAS*, *EBioMedicine*, *Int J Surg*, *Cancer Research*, and *Molecular Therapy*. Has edited and published several monographs including *Comprehensive Treatment of Geriatric Lung Cancer*, *Standardized Surgery for Lung Cancer*, *Atlas of Standardized Lung Cancer Surgery*, and *International Advances and Chinese Practice in Minimally Invasive Lung Resection*. Served as Associate Editor (or contributing author) for multiple textbooks and guidelines, including *Introduction to Clinical Medicine*, *Surgery*, and the *CSCO Guidelines for the Diagnosis and Treatment of Primary Lung Cancer*. **Awards:** Golden Scalpel Award for Honored Physicians (2025), Second Prize of the Science and Technology Award of the China Anti-Cancer Association (2024), "Pioneer in Teaching and Education" Candidate of the Beijing Education System (2023), Outstanding Education Talent for Aid to Tibet in the Tibet Autonomous Region (2022), Peak Talent of the Beijing Hospital Management Center (2020), Beijing Millions of Talents Project (2018), Second Prize of the Huaxia Medical Science and Technology Award (Second Completer) (2016), Recipient of the "Beijing Outstanding Young and Middle-aged Physician" Title (2012). **Main Research Areas:** Surgical treatment and enhanced recovery after surgery (ERAS) for complex and difficult lung and esophageal cancers; clinical research on novel drugs for complex and difficult thoracic tumors; development and application of biomarkers for early diagnosis and differential diagnosis of thoracic tumors; integration of novel digital technologies with the full-process management of lung cancer diagnosis and treatment. **Representative Publications** 1, Yan Wang, Bing Liu, Qingjie Min, Xin Yang, Shi Yan, Yuanyuan Ma, Shaolei li, Jiawen Fan, Yagi Wang, Bin Dong, Huajing Teng, Dongmei Lin, Qimin Zhan and Nan Wu. Spatial transcriptomics delineates molecular features and cellular plasticity in lung adenocarcinoma progression. *Cell Discovery* 2023 Sep 19;9(1):96. doi: 10.1038/s41421-023-00591-7. 2, Liu B, Tao W, Zhou X, Xu LD, Luo Y, Yang X, Min Q, Huang M, Zhu Y, Cui X, Wang Y, Gong T, Zhang E, Huang YS, Chen W, Yan S, Wu N. Multi-omics analysis identifies different molecular subtypes with unique outcomes in early-stage poorly differentiated lung adenocarcinoma. *Mol Cancer*. 2025 May 1;24(1):129. doi: 10.1186/s12943-025-02333-7. 3, Xuantong Zhou, Furong Huang, Gang Ma, Wenqing Wei, Nan Wu and Zhihua Liu. Dysregulated ceramides metabolism by fatty acid 2-hydroxylase exposes a metabolic vulnerability to target cancer metastasis. *Signal Transduction and Targeted Therapy* 2022;7:370 ; https://doi.org/10.1038/s41392-022-01199-1 4, Shenyi Yin, Ying Yu, Nan Wu, Minglei Zhuo, Yanmin Wang, Yanjie Niu, Yiqian Ni, Fang Hu, Cuiming Ding, Hongsheng Liu, Xinghua Cheng, Jin Peng, Juan Li, Yang He, Jiaxin Li, Junyi Wang, Hanshuo Zhang, Xiaoyu Zhai, Bing Liu, Yaqi Wang, Shi Yan, Mailin Chen, Wenqing Li, Jincui Peng, Fei Peng, Ruibin Xi, Buqing Ye, Liyan Jiang, Jianzhong Jeff Xi. Patient-derived tumor-like cell clusters for personalized chemo- and immunotherapies in non-small cell lung cancer. *Cell Stem Cell* 2024;31. 5, Zaizai Dong, Yusen Wang, Gaolian Xu, Bing Liu, Yang Wang, Julien Reboud, Pawel Jajesniak, Shi Yan, Pingchuan Ma , Feng Liu, Yuhao Zhou, Zhiyuan Jin, Kuan Yang, Zhaocun Huang, Minglei Zhuo, Bo Jia , Jian Fang, Panpan Zhang, Nan Wu, Mingzhu Yang , Jonathan M Cooper , Lingqian Chang . Genetic and phenotypic profiling of single living circulating tumour cells from patients with microfluidics. *PNAS* 2024 May 7;121(19):e2315168121. doi: 10.1073/pnas.2315168121 6, Xiang Li, Shanyuan Zhang, Xiang Luo, Guangming Gao, Xiangfeng Luo, Shansi Wang, Shaolei Li, Dachuan Zhao, Yaqi Wang, Xinrun Cui, Bing Liu, Ye Tao, Bufan Xiao, Lei Tang, Shi Yan, and Nan Wu. Accuracy and efficiency of an artificial intelligence-based pulmonary broncho-vascular three-dimensional reconstruction system supporting thoracic surgery: Retrospective and prospective validation study. *eBioMedicine* 2023;87: 104422, https://doi.org/10. 1016/j.ebiom.2022. 104422 7, Lv C, Lu F, Zhou X, Li X, Yu W, Zhang C, Chen K, Du S, Han C, Wang J, Wang Y, Li S, Wang L, Liu Y, Zhang S, Huang M, Song D, Zhao D, Liu B, Wang Y, Cui X, Zhou Z, Yan S, Wu N. Efficacy of a smartphone application assisting home-based rehabilitation and symptom management for patients with lung cancer undergoing video-assisted thoracoscopic lobectomy: a prospective, single-blinded, randomised control trial (POPPER study). *Int J Surg*. 2025 Jan 1;111(1):597-608. doi: 10.1097/JS9.0000000000001845. 8, Ma Y, Kang B, Li S, Xie G, Bi J, Li F, An G, Liu B, Li J, Shen Y, Xu X, Yang H, Yang Y, Gu Y, Wu N, CRISPR-mediated MECOM depletion retards tumor growth by reducing cancer stem cell properties in lung squamous cell carcinoma, *Molecular Therapy* (2022), doi: https:// doi.org/10.1016/j.ymthe.2022.06.011