**Education and Work Experience:** 2012.7 - Present: Department of Oncology, The First Affiliated Hospital, Sun Yat-sen University; Resident Physician, Attending Physician, Associate Chief Physician 2009.9 - 2012.6: Sun Yat-sen University Cancer Center; Master of Oncology 2004.9 - 2009.6: Nanchang University; Bachelor's Degree **Professional Affiliations:** Youth Committee Member, Chemotherapy Professional Committee, Guangdong Anti-Cancer Association Secretary, Lung Cancer Collaboration Group, Tumor Multidisciplinary Diagnosis and Treatment Special Committee, Guangdong Provincial Primary Medical Society Standing Committee Member and Secretary, Tumor Prevention and Rehabilitation Special Committee, Guangdong Provincial Geriatric Health Association Member, Tumor Immunotherapy Special Committee, Guangdong Pharmaceutical Association Member, Esophageal Cancer Branch, Guangdong Provincial Precision Medicine Application Association Member, Spinal Tumor Special Committee, Guangzhou Anti-Cancer Association Member, Urinary and Germ Cell Tumor Special Committee, Guangzhou Anti-Cancer Association Recipient of the 6th "Yangcheng Young Good Doctor" and "Yangcheng Anti-epidemic Good Doctor" Awards **Research Activities:** Publications as first author or corresponding author in the past 5 years: 1, Kai Chen et al. ALYREF-Mediated Regulation of TBL1XR1 and KMT2E Synergistically Upregulates APOC1, Contributing to Oxaliplatin Resistance in Esophageal Cancer. Cancer Res Treat 2025 Feb 4. doi: 10.4143/crt.2024.1091. 2, Kai Chen et al. Inhibition of Apoc1 reverses resistance of sorafenib by promoting ferroptosis in esophageal cancers. Gene 2024 Jan 20:892:147874. doi: 10.1016 3, Kai Chen et al. Deciphering the Hypoxia-immune interface in esophageal squamous carcinoma: a prognostic network model. Front Oncol 2023 Dec 12:13:1296814. doi: 10.3389 4. Authorized 2 utility model patents.