**Education and Professional Experience:** Completed undergraduate, master's, and doctoral studies at Zhongshan Medical College. In 2014, studied clinical diagnosis and treatment of diabetic neuropathy at the University of Sheffield, UK. From 2017 to 2019, served as a visiting scholar at the University of Maryland, USA, conducting research on the mechanisms and genetic analysis of endocrine and metabolic diseases. **Representative Publications:** (1) Xuesi Wan; James Perry; Haichen Zhang; Feng Jin; Kathleen A Ryan; Cristopher Van Hout; Jeffrey Reid; John Overton; Aris Baras; Zhe Han; Elizabeth Streeten; Yanbing Li; Braxton D Mitchell; Alan R Shuldiner; Mao Fu; Regeneron Genetics Center. Heterozygosity for a Pathogenic Variant in SLC12A3 That Causes Autosomal Recessive Gitelman Syndrome Is Associated with Lower Serum Potassium. *Journal of the American Society of Nephrology*, 2021, 32(3): 756-765. (2) Ke, Bin; Ke, Xiao; Wan, Xuesi; Yang, Yubin; Huang, Yingjuan; Qin, Jian; Hu, Chengheng; Shi, Lin. Astragalus polysaccharides attenuates TNF-alpha-induced insulin resistance via suppression of miR-721 and activation of PPAR-gamma and PI3K/AKT in 3T3-L1 adipocytes. *American Journal of Translational Research*, 2017, 9(5): 2195-2206. (3) Huang, Zhimin; Wan, Xuesi; Liu, Juan; Deng, Wanping; Chen, Ailing; Liu, Liehua; Liu, Jianbin; Wei, Guohong; Li, Hai; Fang, Donghong; Li, Yanbing. Short-Term Continuous Subcutaneous Insulin Infusion Combined with Insulin Sensitizers Rosiglitazone, Metformin, or Antioxidant alpha-Lipoic Acid in Patients with Newly Diagnosed Type 2 Diabetes Mellitus. *Diabetes Technology & Therapeutics*, 2013, 15(10): 859-869. (4) Zhu, Dingjun; Wan, Xuesi#; Huang, Hai; Chen, Xu; Liang, Wu; Zhao, Fengjin; Lin, Tianxin; Han, Jinli; Xie, Wenlian. Knockdown of Bmi1 inhibits the stemness properties and tumorigenicity of human bladder cancer stem cell-like side population cells. *Oncology Reports*, 2014, 31(2): 727-736. (5) Shi, Yawei; Wan, Xuesi; Shao, Nan; Ye, Runyi; Zhang, Ning; Zhang, Yunjian. Protective and anti-angiopathy effects of ginsenoside Re against diabetes mellitus via the activation of p38 MAPK, ERK1/2 and JNK signaling. *Molecular Medicine Reports*, 2016, 14(5): 4849-4856. **Monograph:** Co-authored *Endocrinology and Metabolic Diseases*, published by Guangdong Science and Technology Press, February 2018. **Other Major Achievements (e.g., Awards):** Represented the department multiple times in difficult case presentations in Guangdong Province. Won first place in the Guangzhou division of the "First Endocrinology Young Physician Style Competition – Diabetes Standardized Medication Case Presentation" organized by the Guangdong Medical Association.