**Education and Professional Experience:** Professor, Chief Physician, Doctoral Supervisor. Doctor of Internal Medicine (D.Med.) from Sun Yat-sen University; Visiting Scholar in Basic Research at the University of Texas Southwestern Medical Center; Visiting Scholar in Clinical Research at the University of Birmingham, UK. Currently serves as Vice Dean of the Precision Medicine Research Institute, Director of the Drug Clinical Trial Institution, and Deputy Director of the Clinical Research Center at the First Affiliated Hospital of Sun Yat-sen University. Standing Committee Member of the Health Big Data Application Management Committee of the Chinese Hospital Association; Member of the Guangdong Provincial Stem (Somatic) Cell Clinical Research Expert Committee. **Publications:** To date, has published over 40 articles as first author or corresponding author (including co-corresponding author) in internationally renowned journals such as *Lancet Digital Health*, *Hepatology*, *Annals of Oncology*, *Clinical Cancer Research*, and *American Journal of Gastroenterology*. Has led projects funded by the National Natural Science Foundation of China (General Program) and the Guangdong Provincial Department of Industry and Information Technology (Special Financial Projects), with total funding exceeding 12 million RMB. Based on a series of specialized studies, received the 2018 International Digestive Disease Forum Outstanding Scholar Award. Multiple research findings have been recommended by international guidelines for the diagnosis and treatment of digestive diseases. Awarded the First Prize of the Guangdong Provincial Science and Technology Progress Award in 2019. (1) Xiang X, Hao Y, Cheng C, Hu H, Chen H, Tan J, Wang Y, Liu X, Peng B, Liao J, Wang J, Xie Y, Liu J, Chen S, Xu L, Xie W, Xue R, Kuang M, Xu Z, Jiang H, Peng S. A TGF-β-dominant chemoresistant phenotype of hepatoblastoma associated with aflatoxin exposure in children. Hepatology. 2024 Mar 1;79(3):650-665. doi: 10.1097/HEP.0000000000000534. Epub 2023 Jul 17. PMID: 37459556. (2) Xiao H, Weng Z, Sun K, Shen J, Lin J, Chen S, Li B, Shi Y, Kuang M, Song X, Weng W, Peng S. Predicting 5-year recurrence risk in colorectal cancer: development and validation of a histology-based deep learning approach. Br J Cancer. 2024 Apr;130(6):951-960. doi: 10.1038/s41416-024-02573-2. Epub 2024 Jan 20. PMID: 38245662; PMCID: PMC10951272. (3) Wang Y, Xiang X, Chen H, Zhou L, Chen S, Zhang G, Liu X, Ren X, Liu J, Kuang M, Jiang J, She J, Zhang Z, Xue R, Jiang H, Wang J, Peng S. Intratumoral erythroblastic islands restrain anti-tumor immunity in hepatoblastoma. Cell Rep Med. 2023 May 16;4(5):101044. doi: 10.1016/j.xcrm.2023.101044. PMID: 37196629; PMCID: PMC10213871. (4) Chen Z, Zhang G, Ren X, Yao Z, Zhou Q, Ren X, Chen S, Xu L, Sun K, Zeng Q, Kuang M, Kuang DM, Peng S. Cross-talk between Myeloid and B Cells Shapes the Distinct Microenvironments of Primary and Secondary Liver Cancer. Cancer Res. 2023 Nov 1;83(21):3544-3561. doi: 10.1158/0008-5472.CAN-23-0193. PMID: 37352379. (5) Peng H, Chen B, Wei W, Guo S, Han H, Yang C, Ma J, Wang L, Peng S, Kuang M, Lin S. N6-methyladenosine (m6A) in 18S rRNA promotes fatty acid metabolism and oncogenic transformation. Nat Metab. 2022 Aug;4(8):1041-1054. doi: 10.1038/s42255-022-00622-9. Epub 2022 Aug 23. PMID: 35999469. (6) Peng S, Chen S, Hu W, Mei J, Zeng X, Su T, Wang W, Chen Z, Xiao H, Zhou Q, Li B, Xie Y, Hu H, He M, Han Y, Tang L, Ma Y, Li X, Zhou X, Dai Z, Liu Z, Tan J, Xu L, Li S, Shen S, Li D, Lai J, Peng B, Peng Z, Kuang M. Combination Neoantigen-Based Dendritic Cell Vaccination and Adoptive T-Cell Transfer Induces Antitumor Responses Against Recurrence of Hepatocellular Carcinoma. Cancer Immunol Res. 2022 Jun 3;10(6):728-744. doi: 10.1158/2326-6066.CIR-21-0931. PMID: 35476700. (7) Chen S, Xie Y, Cai Y, Hu H, He M, Liu L, Liao C, Wang Y, Wang J, Ren X, Zeng Q, Peng H, Shen S, Li S, Li D, Lai J, Peng B, Ren J, Kuang M, Peng S. Multiomic Analysis Reveals Comprehensive Tumor Heterogeneity and Distinct Immune Subtypes in Multifocal Intrahepatic Cholangiocarcinoma. Clin Cancer Res. 2022 May 2;28(9):1896-1910. doi: 10.1158/1078-0432.CCR-21-1157. PMID: 34526363. (8) Wang F, Wang FH, Sun K, Jiang C, Peng S, Xu LX, Kuang M, Guo GF, Chen SL. PD-1-mAb Plus Regimen in the First and Second Lines of Advanced and Unresectable Biliary Tract Carcinoma: A Real-World, Multicenter Retrospective Analysis. J Inflamm Res. 2022 Oct 31;15:6031-6046. doi: 10.2147/JIR.S364303. PMID: 36339826; PMCID: PMC9635481. (9) Wang J, Deng C, Liu M, Liu Y, Li L, Huang Z, Shang L, Jiang J, Li Y, Mo R, Zhang H, Liu M, Peng S, Xiao H. A fourth dose of the inactivated SARS-CoV-2 vaccine redistributes humoral immunity to the N-terminal domain. Nat Commun. 2022 Nov 11;13(1):6866. doi: 10.1038/s41467-022-34633-7. PMID: 36369243; PMCID: PMC9651894. (10) Liu Y, Zhang H, Yuan G, Yao M, Li B, Chen J, Fan Y, Mo R, Lai F, Chen X, Li M, Chen B, Lord JM, Peng S, Cheng K, Xiao H. The impact of circadian rhythms on the immune response to influenza vaccination in middle-aged and older adults (IMPROVE): a randomised controlled trial. Immun Ageing. 2022 Oct 17;19(1):46. doi: 10.1186/s12979-022-00304-w. PMID: 36253778; PMCID: PMC9574181. (11) Chu H, Liu Z, Liang W, Zhou Q, Zhang Y, Lei K, Tang M, Cao Y, Chen S, Peng S, Kuang M. Radiomics using CT images for preoperative prediction of futile resection in intrahepatic cholangiocarcinoma. Eur Radiol. 2021 Apr;31(4):2368-2376. doi: 10.1007/s00330-020-07250-5. Epub 2020 Oct 8. PMID: 33033863. (12) Chu H, Liu Z, Liang W, Zhou Q, Zhang Y, Lei K, Tang M, Cao Y, Chen S, Peng S, Kuang M. Radiomics using CT images for preoperative prediction of futile resection in intrahepatic cholangiocarcinoma. Eur Radiol. 2021 Apr;31(4):2368-2376. doi: 10.1007/s00330-020-07250-5. Epub 2020 Oct 8. PMID: 33033863. (13) Peng S, Liu Y, Lv W, Liu L, Zhou Q, Yang H, Ren J, Liu G, Wang X, Zhang X, Du Q, Nie F, Huang G, Guo Y, Li J, Liang J, Hu H, Xiao H, Liu Z, Lai F, Zheng Q, Wang H, Li Y, Alexander EK, Wang W, Xiao H. Deep learning-based artificial intelligence model to assist thyroid nodule diagnosis and management: a multicentre diagnostic study. Lancet Digit Health. 2021 Apr;3(4):e250-e259. doi: 10.1016/S2589-7500(21)00041-8. Erratum in: Lancet Digit Health. 2021 Jul;3(7):e413. PMID: 33766289. (14) Chen SL, Xiao H, Xie ZL, Shen JX, Chen ZB, Wang