**Education and Professional Experience:** 2022.05 - Present Deputy Director, Department of Musculoskeletal Oncology, The First Affiliated Hospital, Sun Yat-sen University 2020.12 - Present Chief Physician, Department of Musculoskeletal Oncology, The First Affiliated Hospital, Sun Yat-sen University 2016.01 - 2020.12 Associate Chief Physician, Department of Musculoskeletal Oncology, The First Affiliated Hospital, Sun Yat-sen University 2010.03 - 2011.03 Postdoctoral Fellow, MD Anderson Cancer Center (Ranked #1 in the US) 2000.09 - 2011.07 Completed Bachelor's, Master's, and Doctoral studies at Sun Yat-sen University 2012 - 2018 Selected for the Guangdong Province Outstanding Young Medical Talent Program, Sun Yat-sen University Young Teacher Cultivation Program, The First Affiliated Hospital of Sun Yat-sen University Outstanding Young Talent Support Program, and recognized as a Capable Young and Middle-aged Doctor among the Strongest Departments in Guangdong Hospitals. **Professional Affiliations:** Outstanding Young Medical Talent of Guangdong Province Secretary, Bone Tumor Branch, Guangdong Medical Doctor Association Youth Committee Member, Bone Tumor Group, Orthopedics Branch, Chinese Medical Association Committee Member, Limb Tumor Group, Hand Surgery Branch, Chinese Medical Association Youth Committee Member, Sarcoma Professional Committee, Chinese Anti-Cancer Association Youth Committee Member, Bone Tumor Group, Chinese Research Hospital Association Committee Member, Bone and Soft Tissue Tumor Professional Committee, China Medical Education Association **Publications:** Principal Investigator of over 10 national and provincial research projects, including 4 projects funded by the National Natural Science Foundation of China. Published over 40 SCI-indexed articles, with over 20 as first/corresponding author. Representative works published in mainstream international oncology journals such as *Journal of the National Cancer Institute*, *Clinical Cancer Research*, and *Oncogene*. Academic achievements have been consistently recognized by peers. (1) Tang QL#, Xie XB#, Wang J#, Chen Q, Han AJ, Zou CY, Yin JQ, Liu DW, Liang Y, Zhao ZQ, Yong BC, Zhang RH, Feng QS, Deng WG, Zhu XF, Zhou BP, Zeng YX, Shen JN*, Kang T*. Glycogen synthase kinase-3β, NF-κB signaling, and tumorigenesis of human osteosarcoma. *J Natl Cancer Inst*, 2012, 104(10):749-63. (2) Xie X#, Ghadimi MP, Young ED, Belousov R, Zhu QS, Liu J, Lopez G, Colombo C, Peng T, Reynoso D, Hornick JL, Lazar AJ, Lev D*. Combining EGFR and mTOR blockade for the treatment of epithelioid sarcoma. *Clin Cancer Res*, 2011, 17(18):5901-12. (3) Dongming Lv#, Shirong Ding#, Li Zhong, Jian Tu, Hongbo Li, Hao Yao, Yutong Zou, Ziliang Zeng, Yan Liao, Xuesi Wan, Lili Wen*, Xianbiao Xie*. M6A demethylase FTO-mediated downregulation of DACT1 mRNA stability promotes Wnt signaling to facilitate osteosarcoma progression. *Oncogene*. 2022 Mar;41(12):1727-1741. (4) Hongyi Li#, Jian Tu#, Zhiqiang Zhao#, Lijuan Chen, Yueting Qu, Hongbo Li, Hao Yao, Xiaoshuai Wang, Dung-Fang Lee, Jingnan Shen, Lili Wen, Gang Huang*, Xianbiao Xie*. Molecular signatures of BRCAness analysis identifies PARP inhibitor Niraparib as a novel targeted therapeutic strategy for soft tissue Sarcomas. *Theranostics*. 2020 Jul 25;10(21):9477-9494. (5) Dongming Lv#, Yutong Zou, Ziliang Zeng, Hao Yao, Shirong Ding, Yiying Bian, Lili Wen, Xianbiao Xie*. Comprehensive metabolomic profiling of osteosarcoma based on UHPLC-HRMS. *Metabolomics*. 2020 Nov 18;16(12):120. **Principal Investigator Research Grants:** 1. 2019 National Natural Science Foundation of China (General Program) 2. 2017 National Natural Science Foundation of China (General Program) 3. 2015 National Natural Science Foundation of China (General Program) 4. 2012 National Natural Science Foundation of China (Young Scientists Fund) 5. 2014 Guangdong Provincial Natural Science Foundation (General Program) 6. 2017 Sun Yat-sen University Young Teacher Key Cultivation Project 7. 2013 Sun Yat-sen University Young Teacher Cultivation Program 8. 2012 Ministry of Education Doctoral Program New Teacher Fund 9. 2012 Guangdong Provincial Natural Science Foundation Doctoral Startup Project 10. 2012 The First Affiliated Hospital of Sun Yat-sen University Outstanding Young Talent Support Program **Other Major Achievements (e.g., Awards):** 1. 2020, "Construction Technology and Application of Patient-Derived Tumor Xenograft (PDX) Models," First Prize of Guangdong Provincial Animal Science and Technology Award, 14th Completer.