**Education and Professional Experience:** 1994.08 – 1999.08: Doctoral and Master's Candidate, Orthopedic Surgery (Bone Tumor), Sun Yat-sen University 1999.08 – 2002.12: Attending Physician & Lecturer, Department of Orthopedics, The First Affiliated Hospital of Sun Yat-sen University 2001.08 – 2002.10: Visiting Scholar & AO Fellow, Department of Orthopaedics & Traumatology, Queen Mary Hospital, The University of Hong Kong 2002.12 – 2015.12: Associate Chief Physician, Department of Orthopedics, The First Affiliated Hospital of Sun Yat-sen University 2005 – Present: Deputy Director, Department of Musculoskeletal Oncology, The First Affiliated Hospital of Sun Yat-sen University 2015.12 – Present: Chief Physician, Department of Musculoskeletal Oncology, The First Affiliated Hospital of Sun Yat-sen University **Professional Affiliations:** Member, Bone Tumor Group, Orthopaedic Branch, Chinese Medical Association Deputy Head, Bone Metastasis Group, Sarcoma Committee, Chinese Anti-Cancer Association; Deputy Head, Soft Tissue Sarcoma Group; Deputy Head, Extremity Group; Deputy Head, Reconstruction Group, Bone Tumor and Bone Metastasis Committee Member, Bone Tumor Group, Chinese Association of Orthopaedic Surgeons Member, Bone and Soft Tissue Tumor Committee, China Medical Education Association; Member, Limb Tumor Branch Deputy Director, Orthopedic Repair and Reconstruction Committee, Guangdong Primary Medical Association Chairman, Bone and Soft Tissue Tumor Group, Oncology Branch, Guangdong Medical Association Deputy Head, Bone Tumor Group, 8th Committee, Orthopaedic Branch, Guangdong Medical Association **Research:** Principal Investigator for multiple national and provincial/ministerial research projects. Published over 20 SCI-indexed articles, including 7 as first/corresponding author, with a highest single-article impact factor of 11.21. (1) Hong-Bo Li#, Gang Huang# (Huang Gang, co-first author), Jian Tu#, Dong-Ming Lv, Qing-Lin Jin, Jun-Kai Chen, Yu-Tong Zou, Dung-Fang Lee, Jing-Nan Shen*, Xian-Biao Xie*. METTL14-mediated epitranscriptome modification of MN1 mRNA promote tumorigenicity and all-trans-retinoic acid resistance in osteosarcoma. EBioMedicine. 2022 Aug;82:104142. (2) Hong-Bo Li#, Jun-Kai Chen#, Ze-Xin Su#, Qing-Lin Jin, Li-Wen Deng, Gang Huang* (Huang Gang, corresponding author), Jing-Nan Shen*. Cordycepin augments the chemosensitivity of osteosarcoma to cisplatin by activating AMPK and suppressing the AKT signaling pathway. Cancer Cell International. 2021 Dec 25;21(1):706. (3) Hongyi Li#, Jian Tu#, Zhiqiang Zhao#, Lijuan Chen, Yueting Qu, Hongbo Li, Hao Yao, Xiaoshuai Wang, Dung-Fang Lee, Jingnan Shen, Lili Wen, Gang Huang* (Huang Gang, corresponding author), Xianbiao Xie*. Molecular signatures of BRCAness analysis identifies PARP inhibitor Niraparib as a novel targeted therapeutic strategy for soft tissue Sarcomas. Theranostics. 2020 Jul 25;10(21):9477-9494. (4) Li H#, Xie X#, Yin J, Tu J, Wang X, Liu W, Zhang J, Li H, Zou C, Wang Y, Shen J, Huang G* (Huang Gang, corresponding author). Comparison between low-dose chemotherapy and surgery for the treatment of extremity-associated solitary bone lesions in children with Langerhans cell histiocytosis in South China: A case-control study. Journal of Bone Oncology. 2018 Feb 15;12:1-6. (5) Liao H#, Xie X, Xu Y, Huang G (Huang Gang, corresponding author). Identification of driver genes associated with chemotherapy resistance of Ewing's sarcoma. Onco Targets Ther. 2018 Oct 15;11:6947-6956. **Other Major Achievements (e.g., Awards):** ① First Prize, Ministry of Education, for "Triple Combined Diagnosis, Limb Salvage Treatment, and Basic Research of Malignant Bone Tumors" (Participant) ② Second Prize, Guangdong Provincial Science and Technology Award, for "Triple Combined Diagnosis, Limb Salvage Treatment, and Basic Research of Malignant Bone Tumors" (Participant) ③ Third Prize, Guangzhou Science and Technology Award, for "Proteomic Study of Osteosarcoma-Specific Antigens and Their Diagnostic and Therapeutic Applications" (Participant) ④ First Prize, Guangdong Precision Medicine Science and Technology Award, for "Innovation and Clinical Application of Precision Diagnosis and Treatment Technology for Osteosarcoma" (Participant)