**Education and Professional Experience:** 2007: Graduated from Sun Yat-sen University with a Master's degree in Surgery and commenced work at the hospital. 2007-2010: Resident Physician, Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-sen University. 2010-2019: Attending Physician, Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-sen University. 2014-2017: In-service Doctoral Candidate in Surgery, Sun Yat-sen University. 2019-Present: Associate Chief Physician, Department of Thoracic Surgery, The First Affiliated Hospital, Sun Yat-sen University. **Professional Affiliations:** Member, Cardio-Thoracic Surgery Group, Minimally Invasive Surgery Society, Guangdong Medical Association Member, ERAS Group, Thoracic Surgeons Branch, Guangdong Medical Doctor Association Member, Thoracic Tumor Professional Committee, World Chinese Tumor Physician Association Youth Committee Member, Cross-Straits Medicine Exchange Association Lecturer, Southern China Branch, Thoracic Surgery Academy **Publications:** 1. Lei Y, Xu Q, Zeng B, ZhangW, Zhen Y, Zhai Y, Cheng F, Mei W, Zheng D, Feng J, Lan J, Chen J. Angiotensin-(1-7) protects cardiomyocytes against high glucose-induced injuries through inhibiting reactive oxygen species-activated leptin-p38 mitogen-activated protein kinase/extracellular signal-regulated protein kinase 1/2 pathways, but not the leptin-c-Jun N-terminal kinase pathway in vitro. J Diabetes Investig. 2017 Jul; 8(4): 434-445. 2. Lei Y, Feng Y, Zeng B, Zhang X, Chen J, Zou J, Su C, Liu Z, Luo H, Zhang S. Effect of Prophylactic Thoracic Duct Ligation in Reducing the Incidence of Postoperative Chylothorax during Esophagectomy: A Systematic Review and Meta-analysis. Thorac Cardiovasc Surg. 2017 May 2. 3. Lei Y, Zhen Y, Zhang W, Sun X, Lin X, Feng J, Luo H, Chen Z, Su C, Zeng B, Chen J. Exogenous hydrogen sulfide exerts proliferation, anti-apoptosis, angiopoiesis and migration effects via activating HSP90 pathway in EC109 cells. Oncol Rep. 2016 Jun; 35(6): 3714-3720. 4. Lei YY, Liu ZG, Yang WL. Negative correlation of cytoplasm TIMP3 with miR-222 indicates a good prognosis for NSCLC. Onco Targets Ther. 2018; 11: 5551-5557. 5. Lei YY, Feng YF, Zeng B, Zhang W, Xu Q, Cheng F, Lan J, Luo HH, Zou JYong, Chen ZG, Su CH, Zhen YL, Chen JF. Exogenous H2S promotes cancer progress via activating JAK2/STAT3 signaling pathway in EC109 cells. Int J Clin Exp Patho. 2018; 11(7): 3247-3256. 6. Lei YY, Xu YF, Liu ZG. Estrogen receptor beta 2 inhibits growth of lung transplantation tumors in mice by upregulating P38 mitogen-activated protein kinase. Int J Clin Exp Med. 2019;12(5):5598-605. 7. Lu J, Pan Y, Xia X, Gu Y, Lei Y. Prognostic Significance of mTOR and PTEN in Patients with Esophageal Squamous Cell Carcinoma. Biomed Res Int. 2015; 2015: 417210. (Corresponding Author) 8. Zeng B, Zhang X, Zhao JL, Wei ZW, Zhu HS, Fu MY, Zou DW, Feng YF, Luo HH, Lei YY. The role of DNMT1/hsa-miR-124-3p/BCAT1 pathway in regulating growth and invasion of esophageal squamous cell carcinoma. BMC cancer. 2019 Jun; (19):609. (Corresponding Author) 9. Feng YF, Lei YY, Lu JB, Xi SY, Zhang Y, Huang QT, Wu QL, Wang F. RIT1 suppresses esophageal squamous cell carcinoma growth and metastasis and predicts good prognosis. Cell Death Dis. 2018 Nov; 9(11): 1085. (Co-first Author) 10. Feng Y, Lei Y, Wu X, Huang Y, Rao H, Zhang Y, Wang F. GTF2I mutation frequently occurs in more indolent thymic epithelial tumors and predicts better prognosis. Lung Cancer. 2017 Aug; 110: 48-52. (Co-first Author) 11. Cheang TY, Lei YY, Zhang ZQ, Zhou HY, Ye RY, Lin Y, Wang SM. Graphene oxide-hydroxyapatite nanocomposites effectively deliver HSV-TK suicide gene to inhibit human breast cancer growth. J Biomater Appl. 2018;33(2): 216-226. (Co-first Author) 12. Zeng B, Lei Y, Zhu H, Luo S, Zhuang M, Su C, Zou J, Yang L, Luo H. Aurora-A is a novel predictor of poor prognosis in patients with resected lung adenocarcinoma. Chin J Cancer Res. 2014 Apr; 26(2): 166-173. (Co-first Author) 13. Zhen Y, Wu Q, Ding Y, Zhang W, Zhai Y, Lin X, Weng Y, Guo R, Zhang Y, Feng J, Lei Y, Chen J. Exogenous hydrogen sulfide promotes hepatocellular carcinoma cell growth by activating the STAT3-COX-2 signaling pathway. Oncol Lett. 2018 May; 15(5):6562-6570. (Co-corresponding Author) 14. Chen TF, Xie CY, Rao BY, Shan SC, Zhang X, Zeng B, Lei YY, Luo HH. Surgical treatment to multiple primary lung cancer patients: a systematic review and meta-analysis. BMC Surg. 2019; 19: 185. (Co-corresponding Author) 15. Tang YB, Lei YY, Huang S, Li ZY, Chen XT, Luo HH, Cheng C, Chen J, Zou XN, Chen X. Pristimerin exacerbates cellular injury in conditionally reprogrammed patient-derived lung adenocarcinoma cells by aggravating mitochondrial impairment and endoplasmic reticulum stress through EphB4/CDC42/N-WASP signaling. Oxid Med Cell Longev. 2020. (Co-first Author) **Books:** *Surgical Pathophysiology* (Contributing Author) *Perioperative Pathophysiology and Clinical Practice* (Contributing Author)