**Basic Department Information:** General Surgery is a National Key Clinical Specialty, with Hepatobiliary Surgery as one of its important branches. The department currently has 21 physicians, including 4 doctoral supervisors, 5 master's supervisors, 5 professors, 3 chief physicians, and 4 associate chief physicians. There are 3 lecturers/attending physicians. Among the staff, 19 hold a master's degree and 18 hold a doctoral degree. The department admits approximately 1,500 patients annually and performs over 1,000 surgical procedures. The bed utilization rate is 128.1%, the bed turnover rate is 36.4, and the average length of hospital stay for discharged patients is 14.9 days. The number of critical patient rescues is 42, with a rescue success rate of approximately 99%. **Clinical Work:** The department primarily treats patients with diseases of the liver, biliary tract, pancreas, and spleen, including benign and malignant tumors of the liver, bile ducts, pancreas, and gallbladder. Main conditions include primary liver cancer, cholangiocarcinoma, pancreatic cancer, gallbladder cancer, intrahepatic and extrahepatic bile duct stones, gallstones, benign pancreatic tumors, portal hypertension, appendicitis, and abdominal external hernias. The main clinical research areas are as follows: 1. Treatment of hepatocellular carcinoma complicated with cirrhotic portal hypertension 2. Exploration and evaluation of precise curative treatment techniques for hepatocellular carcinoma 3. Investigation of the efficacy and mechanism of Sorafenib combined with S-1 in treating primary liver cancer 4. Screening and functional analysis of tumor antigens that enhance immunity after microwave ablation of liver cancer 5. Precise hepatectomy for primary liver cancer using computer three-dimensional imaging technology 6. Exploration of molecular biomarkers for predicting the efficacy of Sorafenib in treating liver cancer 7. Investigation of the efficacy and mechanism of S-1 combined with Sorafenib in treating primary liver cancer 8. Clinical study on combined microwave and radiofrequency ablation for small liver cancer 9. Clinical study on the effect of peripheral blood regulatory T lymphocytes on anti-tumor immune response after liver cancer ablation 10. Analysis of the efficacy of hepatectomy for treating intrahepatic bile duct stones **Scientific Research:** In the past 5 years, our department has been awarded 9 National Natural Science Foundation of China (NSFC) grants, 12 Guangdong Provincial Natural Science Foundation grants, and 3 Guangdong Provincial Science and Technology Planning Project grants. We publish approximately 40 papers annually in domestic and international journals, including nearly 20 SCI-indexed papers, and edit 1-2 monographs. Major research projects initiated in the last 3 years include: Study on reducing recurrence after liver cancer ablation by eliminating Gr1+CD11b+ myeloid-derived suppressor cells combined with intratumoral injection of immune microspheres during microwave ablation (NSFC). 1. Study on the inhibitory effect and mechanism of Mir-200 in hepatic stellate cells promoting the development of cirrhosis-related liver cancer (NSFC Youth Fund) 2. Study on the expression pattern and regulatory mechanism of the endocannabinoid system in biliary tract malignancies (NSFC Youth Fund) 3. Study on the role of Elmo1-Nck interaction in the invasion and metastasis of hepatocellular carcinoma (NSFC General Program) 4. Study on serum circulating miRNA expression profiles for early diagnosis and recurrence prediction of liver cancer (NSFC) 5. Anti-liver cancer study by inhibiting Treg combined with intratumoral injection of immune microspheres during microwave ablation (NSFC General Program) 6. Experimental study on adeno-associated virus vector-mediated miR-338-3p therapy for HBV-related liver cancer (NSFC General Program) 7. Study on the role and mechanism of CFTR regulating MUCs expression in the formation of intrahepatic bile duct stones (Guangdong Provincial Natural Science Foundation) 8. Study on the role and significance of Wnt pathway activation, regulation, and methylation of its key factors in hilar cholangiocarcinoma (Guangdong Provincial Natural Science Foundation Doctoral Startup Project) 9. Study on Sorafenib enhancing the anti-liver cancer immunity of GM-CSF/GPC3 DNA vaccine (Guangdong Provincial Natural Science Foundation) 10. In vivo and in vitro experimental study on liver-targeted therapy for hepatocellular carcinoma using tissue factor ultra-small carrier SiRNA (Guangdong Provincial Natural Science Foundation) 11. Study on the role and mechanism of DNA methylation in the tumorigenicity of cholangiocarcinoma side population cells (Guangdong Provincial Natural Science Foundation) 12. Exploration of molecular biomarkers for predicting the efficacy of Sorafenib in treating liver cancer (Guangdong Provincial Natural Science Foundation Doctoral Startup Fund) 13. Study on the protective effect and mechanism of regulatory T cells on hepatic ischemia-reperfusion injury (Guangdong Provincial Natural Science Foundation) 14. Experimental study on treating liver cancer by inhibiting regulatory T cells combined with microwave ablation in situ vaccine (Specialized Research Fund for the Doctoral Program of Higher Education) 15. Analysis of peripheral blood lymphocyte modulation and function after ablation of primary liver cancer (Guangdong Provincial Science and Technology Planning Project) 16. Clinical study on microwave ablation combined with in situ vaccine for treating liver cancer (Guangdong Provincial Science and Technology Planning Project) 17. Study on FoxP3/GPC3-DNA vaccine for treating hepatocellular carcinoma (Guangdong Provincial Science and Technology Planning Project) 18. Downregulation of FAK to inhibit the invasion of liver cancer cells (Guangdong Provincial Science and Technology Planning Project) 19. Establishing miRNA expression profiles for early diagnosis of liver cancer and its metastasis/recurrence using liquid chip technology (Guangdong Provincial Science and Technology Planning Project) 20. Clinical study on the effect of peripheral blood regulatory T lymphocytes on anti-tumor immune response after liver cancer ablation (Guangdong Provincial Science and Technology Planning Project) 21. Clinical study on microwave ablation combined with in situ vaccine for treating liver cancer (Guangdong Provincial Science and Technology Planning Project) **Personnel Training:** The department recruits 3-5 doctoral students and 5-7 master's students annually. Currently, there are 8 doctoral students and 9 master's students. We also accept 15-20 visiting physicians each year. Additionally, the department undertakes teaching responsibilities including large lectures for undergraduate English and Chinese classes, as well as clerkship courses for undergraduate classes, serving as one of the main bases for surgical internships. **Senior Staff (Senior Title):** Kuang Ming, Peng Baogang, Li Shaoqiang, He Qiang, Zhou Qi **Associate Senior Staff (Associate Senior Title):** Li Dongming, Shen Shunli, Hu Wenjie, Hua Yunpeng