Vice President of Research at Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Chief Physician and Doctoral Supervisor in the Department of Cardiology. Specializes in minimally invasive intervention and pharmacological treatment of complex and critical coronary artery disease, congenital heart disease, valvular heart disease, and structural heart disease such as left atrial appendage occlusion. Research findings have been incorporated into international cardiovascular internal medicine textbooks and European clinical guidelines for cardiovascular disease and other industry standards, with total citations exceeding 3,000. Has received the "Wu Mengchao Medical Youth Award," "Shulan Medical Youth Award," and "Shanghai Academic Leader" titles, among others. National-level major and key research projects led in the past 5 years: 1. National Natural Science Foundation of China Key Project, Grant No. 82230014, "Impact of Circadian Rhythm Disruption on the Development and Progression of Abdominal Aortic Aneurysm: The Key Role of the Circadian Nuclear Receptor REV-ERBα," 2023/01/01-2027/12/31, 2.63 million RMB, In Progress, Principal Investigator. 2. National Natural Science Foundation of China Key Project, Grant No. 81930007, "Impact of Circadian Rhythm on Post-Infarction Myocardial Repair and Remodeling: The Key Role of the Circadian Nuclear Receptor RORα Signaling Pathway," 2020/01/01-2024/12/31, 2.97 million RMB, In Progress, Principal Investigator. 3. National Key Research and Development Program, Grant No. 2018YFC1312800, "Development and Effect Evaluation of an Innovative Health Management Model for 'Collaborative Prevention and Shared Management' of Cardiovascular and Cerebrovascular Diseases," 2018/09-2021/12, 15.34 million RMB, In Progress, Project Leader and Chief Scientist. Representative publications in the past 5 years (only those with IF>10 listed) 1. Sun LY#, Lyu YY#, Zhang HY, Shen Z, Lin GQ, Geng N, Wang YL, Huang L, Feng ZH, Guo X, Lin N, Ding S, Yuan AC, Zhang L, Qian K, Pu J*. Nuclear Receptor NR1D1 Regulates Abdominal Aortic Aneurysm Development by Targeting the Mitochondrial Tricarboxylic Acid Cycle Enzyme Aconitase-2. Circulation. 2022 Jul 26:101161CIRCULATIONAHA121057623. doi: 10.1161/CIRCULATIONAHA.121.057623. Epub ahead of print. 2. Zhao Y#, Lu X#, Wan F, Gao L, Lin N, He J, Wei L, Dong J, Qin Z, Zhong F, Qiao Z, Wang W, Ge H, Ding S, Yang Y, Xiu J, Shan P, Yan F, Zhao S, Ji Y, Pu J *. Disruption of circadian rhythms by shift work exacerbates reperfusion injury in myocardial infarction. J Am Coll Cardiol. 2022. 79(21):2097-2115. 3. Shi JF#, Tong RY#, Zhou M#, Gao Y, Zhao YC, Chen YF, Liu WH, Li GX, Lu D, Meng GF, Yuan AC, Hu LH, Pu J*. Circadian nuclear receptor Rev-erbα is expressed by platelets and regulates platelet activation and thrombus formation. Eur Heart J. 2022. 43(24):2317-2334. 4. Zhao YC#, Gao LC#, Jiang CL, Chen JQ, Qin ZH, Zhong FY, Yang Y, Tong RY, Zhou M, Yuan AC, Pu J*. The transcription factor ZHX2 alleviates nonalcoholic steatohepatitis by transcriptional activation of PTEN. Hepatology. 2021. 1866(11): 165890. 5. Jiang P#, Feng ZH#, Sheng L#, Hu CX, Ma X, Zhang SY, Wu, LM, Xiao X, Wang QX, Guo CJ, Qiu DK; Fang JY, Xu JR, Gershwin Merrill Eric, Jiang M*, Ma X*, Pu J*. Morphological, functional and tissue characterization of silent myocardial involvement in patients with primary biliary cholangitis. Clin Gastroenterol Hepatol. 2021.S1542-3565(21):00915. 6. Gu ZC#, Wei AH#, Zhang C#, Wang XH, Zhang L, Shen L, Li Z, Pan MM, Liu XY, Pu J*, Lin HW*. Risk of major gastrointestinal bleeding with new vs conventional oral anticoagulants: a systematic review and meta-analysis. Clin Gastroenterol Hepatol. 2020.18(4):792-799. 7. Leng S#, Ge H#, He J, Kong L, Yang Y, Yan F, Xiu J, Shan P, Zhao S, Tan RS, Zhao X, Koh AS, Allen JC, Hausenloy DJ, Mintz GS, Zhong L, Pu J*. Long-term prognostic value of cardiac MRI left atrial strain in ST-segment elevation myocardial infarction. Radiology.2020.296(2):299-309. 8. Xu L#, Su Y#, Zhao Y#, Sheng X, Tong R, Ying X, Gao L, Ji Q, Gao Y, Yan Y, Yuan A, Wu F, Lan F, Pu J*. Melatonin differentially regulates pathological and physiological cardiac hypertrophy: Crucial role of circadian nuclear receptor RORα signaling. J Pineal Res.2019.67(2): e12579. 9. Ding S#, Lin N#, Sheng X#, Zhao Y, Su Y, Xu L, Tong R, Yan Y, Fu Y, He J, Gao Y, Yuan A, Ye L, Reiter RJ, Pu J*. Melatonin stabilizes rupture-prone vulnerable plaques via regulating macrophage polarization in a nuclear circadian receptor RORα-dependent manner. J Pineal Res.2019.67(2): e12581. 10. Zhao Y#, Wang F#, Gao L#, Xu L, Tong R, Lin N, Su Y, Yan Y, Gao Y, He J, Kong L, Yuan A, Zhuge Y, Pu J*. Ubiquitin-specific protease 4 is an endogenous negative regulator of metabolic dysfunctions in nonalcoholic fatty liver disease. Hepatology.2018.68(3):897-917. 11. Guo Q#, Wu LM#, Wang Z, Shen JY, Su X, Wang CQ, Gong XR, Yan QR, He Q, Zhang W, Xu JR*, Jiang M*, Pu J*. Early detection of silent myocardial impairment in patients with new onset drug-naïve systemic lupus erythematosus -- a three-center prospective study. Arthritis & Rheumatology.2018.70(12):2014-2024. 12. Pu J*, Ding S, Ge H, Han Y*, Lin R, Guo J, Lin R, Su X, Zhang H, Chen L, He B*. EARLY-MYO investigators (early routine catheterization after alteplase fibrinolysis versus primary PCI in acute ST-segment-elevation myocardial infarction). Circulation.2017.136(16):1462-1473. 13. Zhao Y#, Xu L#, Ding S#, Lin N, Ji Q, Gao L, Su Y, He B*, Pu J*. Novel protective role of the circadian nuclear receptor retinoic acid-related orphan receptor-α in diabetic cardiomyopathy. J Pineal Res.2017.62(3):12378. 14. Deng KQ#, Wang A#, Ji YX#, Zhang XJ, Fang J, Zhang Y, Zhang P, Jiang X, Gao L, Zhu XY, Zhao Y, Gao L, Yang Q, Zhu XH, Wei X, Pu J*, Li H*. Suppressor of IKKε is an essential negative regulator of pathological cardiac hypertrophy. Nat Commun.2016.7:11432. 15. He B, Zhao Y, Xu L, Gao L, Su Y, Lin N, Pu J*. The nuclear melatonin receptor RORα is a novel endogenous defender against myocardial ischemia/reperfusion injury. J Pineal Res.2016.60(3):313-326. 16. Ying X#, Zhao Y#, Yao T, Yuan A, Xu L, Gao L, Ding S, Ding H, Pu J*, He B*. Novel protective role for ubiquitin-specific protease 18 in pathological cardiac remodeling. Hypertension. 2016.68(5):1160-1170. 17. He B, Zhao YC, Gao LC, Ying XY, Xu LW, Su YY, Ji QQ, Lin N, Pu J*. Ubiquitin-specific protease 4 is an endogenous negative regulator of pathological cardiac hypertrophy. Hypertension. 2016.67(6):1237-1248. 18. Pu J, Mintz GS, Biro S, Lee JB, Stone GW, Weisz G, Maehara A*. Insights into echo-attenuated plaques, echolucent plaques, and plaques with spotty calcification: novel findings from comparisons among intravascular ultrasound, near-infrared spectroscopy, and pathological histology in 2,294 human coronary artery segments. J Am Coll Cardiol.2014.63(21):2220-2233. 19. Pu J#, Yuan A#, Shan P, Gao E, Wang X, Wang Y, Lau W, Ma XL*, He B*. Cardiomyocyte expressed farnesoid-X-receptor is a novel apoptosis mediator and contributes to myocardial ischemia/reperfusion injury. Eur Heart J