The Department of Ultrasound Medicine at Peking University Third Hospital was founded in 1960 and officially established as a department in 1987, making it one of the earliest specialized ultrasound medicine departments in China. Having undergone developmental stages as an ultrasound diagnostic unit and subsequently an ultrasound diagnostic department, it was renamed the Department of Ultrasound Medicine in 2022. Its development history epitomizes the pioneering journey of ultrasound medicine in China. Under the leadership of its first department director, Professor Zhang Wu (November 8, 1936 – December 21, 2019), the department actively engaged in international exchange and collaboration from its early years. Professor Zhang Wu studied in the United States and Canada on multiple occasions, and in 1977, he invited Professor Dennis White, President of the World Federation for Ultrasound in Medicine and Biology, and Professor Toshio Wagai, a Japanese ultrasound expert, to visit China, fostering important connections between the domestic ultrasound community and North America and Japan. In the same year, Professor Zhang Wu was invited to assist Friendship Hospital in pioneering B-mode ultrasound diagnostic services in China. In 1984, he further assisted nearly 20 county-level hospitals in the Yunnan region in establishing modern B-mode ultrasound diagnostic units, laying the foundation for enhancing grassroots ultrasound diagnostic capabilities across the country. Under his leadership, the departmental team took the lead in conducting foundational research in China, including ultrasound normal value measurements, publishing a series of seminal papers that established industry standards. In the 1990s, the department introduced and promoted ultrasound-guided automated biopsy technology, earning the Third Prize for Science and Technology Progress from the Ministry of Health in 1993. Beginning in 1992, the department consecutively hosted 13 national-level interventional ultrasound training programs, training over 800 grassroots physicians, supplying substantial technical talent nationwide, and advancing the widespread adoption of this technology across China. In 2000, Professor Wang Jinrui pioneered clinical and foundational research in contrast-enhanced ultrasound in China. His edited work, *Practical Abdominal Ultrasound Diagnosis*, has become an authoritative reference in the field, earning the Ninth China Book Award and the Second Prize for Beijing Science and Technology Progress. Through the pioneering efforts and leadership of successive department directors, including Zhang Wu, Wang Jinrui, and Jia Jianwen, the department has evolved into a clinical and research platform with a leading academic standing in China and significant influence. **Professional Team and Service Scale** The department currently has 78 staff members, including 13 chief physicians, 13 associate chief physicians, one principal investigator and one associate principal investigator, and two postdoctoral researchers. Over 45% of the staff hold doctoral degrees, forming a well-structured professional team with exceptional technical expertise and profound academic achievement. The department comprises multiple specialized divisions, including abdominal, superficial organ, vascular, musculoskeletal, and interventional ultrasound. It handles over 1.11 million patient visits annually, with annual interventional diagnostic and therapeutic procedures exceeding 10,000 cases, placing its service volume and technical complexity among the highest in China. The Department of Ultrasound Medicine at PUTH strengthens its coordinated development strategy of "one department, multiple campuses." It has established a comprehensive medical network centered on the main Haidian campus, extending to the Central Party School Campus, Capital International Airport Campus, Northern Campus, and Haidian North Campus. This multi-dimensional clinical service system integrates outpatient and emergency care, interventional wards, pain management, and the International Medical Center. **Specialized Diagnostic and Therapeutic Programs** As a major birthplace of musculoskeletal ultrasound in China, the department has systematically conducted clinical and research work in musculoskeletal ultrasound since the 1990s. Since Professor Wang Jinrui led the translation of *Ultrasound Diagnosis of the Musculoskeletal System* in 1992, the department has undergone over two decades of leapfrog development, establishing a nationally leading musculoskeletal ultrasound diagnostic and therapeutic system. Through deep collaborations with internationally renowned institutions, including Thomas Jefferson University Hospital in the United States and London Health Sciences Centre at Western University in Canada, a comprehensive musculoskeletal ultrasound diagnostic and training system has been established. Since 2007, the department has consecutively hosted international musculoskeletal ultrasound symposiums, and in 2014, it established the "Peking University Third Hospital Musculoskeletal Ultrasound Training Center" in collaboration with Thomas Jefferson University. As of 2025, leveraging its pioneering "anatomy-clinical-imaging three-dimensional integrated teaching system," the department has successfully conducted 19 national-level continuing education programs in musculoskeletal ultrasound, systematically training over 2,000 specialized professionals and establishing itself as a core talent cultivation base for the field. In 2019, the PUTH Musculoskeletal Ultrasound Specialty Medical Consortium was established, encompassing 275 hospital ultrasound departments with regional representation across 31 provinces and municipalities nationwide. This has created a high-quality musculoskeletal ultrasound network radiating from Beijing to the entire country, advancing the standardized development of musculoskeletal ultrasound in China. The department's interventional diagnostic and therapeutic system has become increasingly comprehensive. Needle biopsy techniques cover multiple organs throughout the body, including the brain, orbital tumors, thyroid, thorax and lungs, abdominal organs, and prostate. It is one of the earliest centers in China to systematically perform ultrasound-guided fine-needle aspiration cytology. In recent years, leveraging the strengths of PUTH's orthopedics, pain management, and sports medicine departments, the department has developed ultrasound-guided pain management and nerve block techniques to alleviate patient suffering. Furthermore, ultrasound-guided minimally invasive interventional treatments, including thermal ablation of space-occupying lesions in the thyroid, parathyroid, and liver, have achieved favorable clinical outcomes characterized by precision and minimal invasiveness. **Research Innovation and Translational Outcomes** The department places high priority on research innovation and has established a research framework led by national-level projects, driven by clinical questions, and integrating multidisciplinary approaches. With strong institutional support, the "Ultrasound Medicine and Molecular Imaging Research Laboratory" was formally established in 2017, adopting a new development model emphasizing "equal emphasis on clinical and research excellence, integrating fundamental and translational approaches." The laboratory is dedicated to cutting-edge research in multifunctional ultrasound contrast agents, targeted drug delivery vehicles, ultrasound molecular imaging, and precision diagnosis and treatment of tumors. Collaborating with institutions including the Chinese Academy of Sciences, Tsinghua University, and Peking University, the laboratory conducts research addressing critical clinical challenges such as malignant tumor drug resistance, recurrence and metastasis, and blood-brain barrier penetration, establishing an innovative medical-engineering integrated research system. Over the past five years, the laboratory has published numerous high-impact SCI papers in leading journals including *Nature Communications*, *Advanced Materials*, and *ACS Nano* (31 papers with IF>10), accumulating over 5,000 citations in domestic and international academic journals. The laboratory has been awarded national and provincial-level research grants, including the "National Excellent Young Scientists Fund," "Beijing Outstanding Young Scientist Fund," and "National Key Research and Development Program," and has joined the "State Key Laboratory of Vascular Homeostasis and Remodeling" and the "Beijing Key Laboratory of Gastrointestinal Early Cancer Medical-X Collaborative Innovation." The department possesses formidable research capabilities, having undertaken over 130 national and provincial-level projects, including the National Natural Science Foundation of China and National Key Research and Development Programs, with current research funding exceeding 10 million RMB. As of 2025, the department has published over 500 academic papers, including more than 200 SCI papers, authored or co-authored over 20 monographs, and obtained over 100 authorized national patents. The invention patent "Integrated Isolation and Acoustic Coupling Device for Intracavitary Ultrasound Probes" won the First Prize in the 2019 PUTH Innovation and Translation Competition, and "Key Technologies and Applications of Antimicrobial Polyurethane Coatings for Medical Devices" received the Second Prize from the China Invention Association. Multiple achievements are currently advancing toward clinical translation. The department-developed "Perfluoropropane Microbubbles for Injection" has completed Phase III clinical trials, overcoming the critical technical bottleneck in ultrasound contrast agent preparation and achieving independent domestic production of ultrasound contrast agents, which holds significant clinical implications for ultrasound diagnosis and therapy. **Educational Heritage and Talent Development** Rooted in the academic excellence of Peking University Health Science Center, the Department of Ultrasound Medicine at PUTH has consistently upheld the educational philosophy of "discipline-based teaching, compassion-driven practice." Through unwavering dedication, the department has established a comprehensive teaching system spanning undergraduate, master's, and doctoral education, making pioneering contributions to the cultivation of high-level talent in ultrasound medicine in China. In 2015, it became one of Beijing's first standardized residency training bases, and in 2017, it ranked first in Beijing in the dynamic evaluation of training bases. Since the 1970s, the department has pioneered advanced clinical training programs, and over the past decade, it has trained approximately 1,600 professionals from 31 provinces and municipalities nationwide. In 2022, the department innovatively launched the first National Ultrasound Advanced Training Physicians Case Competition, followed by the first Advanced Training Physicians Forum in 2025. Through distinctive educational models including weekly multidisciplinary discussions of challenging cases and distinguished faculty lectures, the department has pioneered the "mentor-trainee" dual-track development pathway for visiting scholars in China, continuously deepening the connotation of its teaching system and establishing itself as a benchmark for ultrasound medicine education in China. **Social Responsibility and Industry Leadership** The dedication and perseverance of previous generations laid the foundation for the department's distinguished achievements. The new generation of leadership, including current department director Professor Cui Ligang and the core team, will carry forward this legacy, uniting efforts and striving toward the goal of building a world-class ultrasound medicine center. Committed to the exhaustive pursuit of medical knowledge and the relentless pursuit of excellence, the Department of Ultrasound Medicine at PUTH upholds the institutional motto of "Unity, Dedication, Pragmatism